Isotonitazene, also called “iso,” is a designer drug that was first made decades ago as a pain relief treatment, like many other synthetic opioids. The drug is derived from a powerful opioid called etonitazene, which gives it both its pain-relieving properties and the “high” that users seek. All opioids come with certain risks attached to them, even if they are legally prescribed. But isotonitazene and other synthetic opioids are particularly dangerous because they are often combined with other lethal drugs

What is Isotonitazene

Isotonitazene is a benzimidazole derived opioid analgesic drug related to etonitazene, which has been sold as a designer drug. It has only around half the potency of etonitazene in animal studies, but it is likely less potent in humans as was seen with etonitazene (1000 times as potent as morphine in animal models yet only 60 times as potent in humans)

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Side effects of benzimidazole derived opioids are expected to be similar to those of fentanyl, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Isotonitazene has been detected in multiple fatalities in the U.S. since August 2019.

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Isotonitazene (obtained from an online vendor) was fully characterized in November 2019 in a paper where the authors performed a full analytical structure elucidation in addition to determination of the potency at the μ-opioid receptor using a biological functional assay in vitro. While iso was not compared directly to morphine in this assay, it was found to be around 2.5 times more potent than hydromorphone and slightly more potent than fentanyl.

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All opioids come with certain risks attached to them, even if they are legally prescribed. But isotonitazene and other synthetic opioids are particularly dangerous because they are often combined with other lethal drugs. For example, the iso overdoses in Indiana and Illinois occurred when iso was taken alongside cocaine.

Other names: iso, Nitazene, Toni, CAS 14188-81-9

What are the Effects of Isotonitazene