JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678 is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, with some selectivity for CB₂. It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products that in some countries are sold legally as “incense blends”.

What is JWH-018

At least one case of JWH-018 dependence has been reported by the media. The user consumed JWH018 daily for eight months. Withdrawal symptoms were more severe than those experienced as a result of cannabis dependence. JWH-018 has been shown to cause profound changes in CB₁ receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids.

Where to Get AM-678

JWH-018 is a full agonist of both the CB₁ and CB₂ cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB₁ and 2.94 ± 2.65 nM at CB₂. JWH018 has an EC₅₀ of 102 nM for human CB₁ receptors, and 133 nM for human CB₂ receptors. JWH-018 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, suggesting potent cannabinoid-like activity.

How to Use JWH018

JWH-018 usage is readily detected in urine using “spice” screening immunoassays from several manufacturers focused on both the parent drug and its omega-hydroxy and carboxyl metabolites. JWH018 will not be detected by older methods employed for detecting THC and other cannabis terpenoids. Determination of the parent drug in serum or its metabolites in urine has been accomplished by GC-MS or LC-MS. Serum JWH-018 concentrations are generally in the 1–10 μg/L range during the first few hours after recreational usage.

Effects of JWH-018

Compared to THC, which is a partial agonist at CB₁ receptors, JWH-018, and many synthetic cannabinoids, are full agonists. THC has been shown to inhibit GABA receptor neurotransmission in the brain via several pathways. JWH018 may cause intense anxiety, agitation, and, in rare cases (generally with non-regular JWH users), has been assumed to have been the cause of seizures and convulsions by inhibiting GABA neurotransmission more effectively than THC. Cannabinoid receptor full agonists may present serious dangers to the user when used to excess.

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Other Names: 1-Pentyl-3-(1-naphthoyl)indole, CAS CAS 209414-07-3, JWH-018, JWH 018,JWH018, AM-678, AM 678, 1-pentyl-3-(1-naphthoyl)-indole, Spice, K2, Legal Weed, Synthetic Cannabis, Herbal Incense, Atomic Bomb, Dragon, Monkees Go, Bananas, Rockstar, Spike 99, Ultra, Wasted.

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