Mephedrone also known as 4-methyl methcathinone (4-MMC) or 4-methyl ephedrone, is an aromatic ketone that is propiophenone substituted at C-4 and at C-beta with methyl and methylamino groups respectively. It is a synthetic stimulant and entactogen drug of the amphetamine and cathinone classes. It has a role as a xenobiotic and an environmental contaminant. It is a member of amphetamines, an aromatic ketone and a secondary amino compound. It derives from a propiophenone.
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Mephedrone is a recent designer drug, commonly referred to as bath salts, and is one of the most popular recreationally used new psychoactive substances. Like MDMA, it shares similarities with stimulants and with hallucinogens, and psychopharmacological research indicates that it is similar to stimulant drugs, such as amphetamines. Although 4-MMC it has been popularized as a safer alternative, there are medical risks associated with this drug, and the risks are similar to those of amphetamines.
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The typical first session lasted for 6 hours, and other drugs were used in conjunction with mephedrone. On this first occasion of use, participants reported drinking alcohol, using cocaine, taking MDMA, smoking cannabis, and/or taking ketamine. Although new on the drug scene, there has been some limited research documenting the effects of mephedrone. This is what users say it feels like to get high on mephedrone.
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Mephedrone (4-methylmethcathinone) is one of a number of synthetic cathinones that have emerged as novel psychoactive substances (NPS). 4-MMC as it is the most widely used cathinone and the one for which there is the most published literature. Mephedrone is most commonly available in powder form, but it is also available as tablets and capsules. The most common routes of use are nasal insufflation and oral ingestion: there are also reports of use by rectal insertion and intravenous/intramuscular injection.
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Mephedrone is a monoamine releasing agent. It is a chiral compound and both of its enantiomers display similar potency as substrates at dopamine transporters. R-Mephedrone is much less potent than S-mephedrone as a substrate at serotonin transporters. The keto oxygen renders 4-MMC more hydrophilic than the corresponding methylamphetamines, which may account for the higher doses required to achieve a similar effect, because 4-MMC is less able to cross the blood–brain barrier.
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Slang names include drone, M-CAT, White Magic, Meow Meow, Miow, Meph, MC, M-Smack, Charge, Bubble, Bounce, 4-MMC, CAS 1189805-46-6, Mad cow, CAS 88783-39-5, 4-methylephedrone, bk-4-methylmethamphetamine