Methoxyacetylfentanyl belongs to the 4-anilidopiperidine class of synthetic opioids. This class also includes fentanyl, which is internationally controlled, and a number of other fentanils. Methoxyacetyl fentanyl differs from fentanyl due to the replacement of the propionamide group with a 2-methoxyacetamide group. Methoxyacetylfentanyl is also structurally related to ocfentanil.

What is Methoxyacetylfentanyl 

Methoxyacetylfentanyl is an opioid receptor agonist. Currently available data on the pharmacodynamics of methoxyacetyl fentanyl are limited to studies investigating its binding and functional activity at opioid receptors in vitro, and its anti-nociceptive properties in mice. The in vitro data shows that methoxyacetylfentanyl is a highly selective μ-opioid receptor agonist and that it is less potent than morphine and fentanyl. Data from studies in mice examining the anti-nociceptive properties of methoxyacetylfentanyl shows that the substance reduces the response to experimentally induced pain with a similar potency to other controlled fentanils.

How to Use Methoxyacetylfentanyl 

Side effects of methoxyacetylfentanyl are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear. A new wave of fentanyl analogues and associated deaths began in around 2014 in the US, and have continued to grow in prevalence; especially since 2016 these drugs have been responsible for hundreds of overdose deaths every week.

What are the Effects Methoxyacetylfentanyl  

As with other fentanils, methoxyacetylfentanyl can be administered orally as a powder (including in capsules), as tablets, or as a solution (using nasal sprays), or by insufflation of a powder; it can also be administered intranasally or sublingually via a spray; inhaled by smoking or vaporizing; and, administered by injection (intravenous and intramuscular). Blotters containing fentanils have also been described. It is not possible to currently discern the ‘typical’ dosages administered by users and these appear to differ depending on factors such as the route of administration, the tolerance of the users, the use of
other drugs, and the desired effects.

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Due to its lipophilicity, methoxyacetylfentanyl should be rapidly absorbed and readily cross the blood brain barrier. A recent study indicates that the metabolic pathway of methoxyacetyl fentanyl shares some similarities with other fentanils. Consequently, drug-drug interactions observed with fentanyl might equally apply. The concomitant use of other central nervous system (CNS) depressants, including other opioids, sedatives/hypnotics, ethanol, pregabalin, gabapentin, tranquillisers, and sedating anti-histamines, may produce additive depressant effects.

How Does Methoxyacetyl fentanyl Looks Like

From the available data, the psychological and behavioural effects of methoxyacetylfentanyl may share some similarities with fentanyl and other opioid analgesics. These would include relaxation and euphoria; at higher doses, sedation and profound intoxication may occur.

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Other names: MAF, Methoxy, Synthetic Heroin, Methoxyacetyl Fentanyl, Methoxyacetyl-F, Methoxy-AcF, Methoxyacetyl Fentanyl, Desfluoro Ocfentanil, Ching, CAS 101345-67-9

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